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- 000 01911nam0 2200277 450
- 010 __ |a 978-7-122-16778-1 |d CNY168.00 |b 精装
- 100 __ |a 20130801d2013 em y0chiy0110 ea
- 102 __ |a CN |b 110000 |2 GB2260
- 200 1_ |a 多肽化学与生物学 |A Duo Tai Hua Xue Yu Sheng Wu Xue |d = Peptides chemistry and biology |f 刘克良, 程卯生, 孟庆斌主编 |z eng
- 210 __ |a 北京 |c 化学工业出版社 |d 2013.7
- 215 __ |a 156页 |c 图表 |d 24cm
- 330 __ |a A group of eight closely related acyl depsipeptides (ADEPs) as antibiotics hasbeen previously isolated from the fermentation broth of Streptococcus hawaiiensisNRRL 15010 and briefly described as the `A54556 complex` in a patentl`J. Thesecompounds all contain a proline-rich macrocyclodepsipeptidolactone with adifferentially substituted aromatic usual or unusual amino acid, which isN-acylated by a different specific fatty acid. The solid phase synthesis of theseADEPs is complicated by three factors: (a) the cyclic nature of the peptide, (b) thelactone functionality, and (c) the presence of several non-proteinogenic aminoacids with in vitro activity against staphylococci and streptococci. However, noinformation is available regarding the in vivo potency or mechanism of action ofthese ADEPs. The reported structures of natural product ADEP l (`factor A`) andits optimized congeners are shown in Fig. 1. Generally, they have some variationsin some residues and one "unusual" fatty acid.
- 517 1_ |a Chemistry and Biology英文 |A Chemistry and Biology Ying Wen
- 606 0_ |a 多肽 |A Duo Tai |x 生物学 |x 英文 |j 文集
- 606 0_ |a 多肽 |A Duo Tai |x 化学 |x 英文 |j 文集
- 701 _0 |a 孟庆斌 |A Meng Qing Bin |4 主编
- 701 _0 |a 程卯生 |A Cheng Mao Sheng |4 主编
- 701 _0 |a 刘克良 |A Liu Ke Liang |4 主编
- 801 _0 |a CN |b 安徽新华 |c 20131120
- 905 __ |a LIB |d Q516-53/1