MARC状态：审校 文献类型：中文图书 浏览次数：10
- 题名/责任者:
- 多肽化学与生物学/刘克良, 程卯生, 孟庆斌主编
- 出版发行项:
- 北京:化学工业出版社,2013.7
- ISBN及定价:
- 978-7-122-16778-1 精装/CNY168.00
- 载体形态项:
- 156页:图表;24cm
- 其它题名:
- Chemistry and Biology英文
- 个人责任者:
- 孟庆斌 主编
- 个人责任者:
- 程卯生 主编
- 个人责任者:
- 刘克良 主编
- 学科主题:
- 多肽-生物学-英文-文集
- 学科主题:
- 多肽-化学-英文-文集
- 中图法分类号:
- Q516-53
- 提要文摘附注:
- A group of eight closely related acyl depsipeptides (ADEPs) as antibiotics hasbeen previously isolated from the fermentation broth of Streptococcus hawaiiensisNRRL 15010 and briefly described as the `A54556 complex` in a patentl`J. Thesecompounds all contain a proline-rich macrocyclodepsipeptidolactone with adifferentially substituted aromatic usual or unusual amino acid, which isN-acylated by a different specific fatty acid. The solid phase synthesis of theseADEPs is complicated by three factors: (a) the cyclic nature of the peptide, (b) thelactone functionality, and (c) the presence of several non-proteinogenic aminoacids with in vitro activity against staphylococci and streptococci. However, noinformation is available regarding the in vivo potency or mechanism of action ofthese ADEPs. The reported structures of natural product ADEP l (`factor A`) andits optimized congeners are shown in Fig. 1. Generally, they have some variationsin some residues and one "unusual" fatty acid.
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| 索书号 | 条码号 | 年卷期 | 校区—馆藏地 | 书刊状态 |
| Q516-53/1 | S2341803 | 总馆—自然书库（凤阳） | 可借 | |
| Q516-53/1 | S2341804 | 总馆—自然书库（凤阳） | 可借 |
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